Dorsalrootganglion相关论文
晚期糖基化终末产物受体(RAGE)是一种新的模式识别受体，在免疫细胞和神经细胞均有表达。研究显示，RAGE的异常激活参与病理性疼痛的发......
Axonal regeneration plays an important role in functional recovery after nervous system damage. However, after axonal in......
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High-Voltage-Activated Calcium Channel in the Afferent Pain Pathway: An Important Target of Pain The
High-voltage-activated (HVA) Ca2+ channels are widely expressed in the nervous system.They play an important role in pai......
Noxious mechanical information is transmitted through molecularly distinct nociceptors,with pinprickevoked sharp sensiti......
Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Spec
Voltage-gated sodium channels (Navs) play an important role in human pain sensation.However,the expression and role of N......
Neonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visc
The pathophysiology of visceral pain in patients with irritable bowel syndrome remains largely unknown.Our previous stud......
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Influence of peripheral nerve injury upon Slit-Robo GTPase-activating protein gene expression in dor
Objective: To investigate the expression change of members of srGAP family mRNA and protein following SCNT....
Clinical study of correlation between mean radiation doses on dorsal root ganglion regions and the s
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Peripheral inflammation induces promoter demethylation of endogenous hydrogen sulfide synthesis enzy
Objective Chronic pain associated with inflammation is a common clinical problem, and the underlying mechanisms have onl......
Antisense-mediated knockdown of Nav1.8,but not Nav1.9,generates inhibitory effects on complete Freun
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Sensitization of sodium channels contributes to colonic visceral hypersensitivity in diabetic rats a
Background:Intestinal dysfunction is a common chronic complication of diabetes mellitus,the underlying mechanisms of col......
Dexmedetomidine inhibits Tetrodotoxin-resistant Nav1.8 sodium channel activity through Gi/o-dependen
Background: Systemically administered dexmedetomidine(DEX),a selective α2 adrenergic receptor(α2-AR)agonists,produces ......
IL-6-mediated functional up-regulation of TRPV1 receptors in DRG neurons via the activation of JAK/P
Objective Primary and metastatic cancers that affect bone are frequently associated with severe and intractable pain....
The treatment of bone cancer pain remains a clinically challenging problem.Here, we report that A-type K+ channels in pr......
Objective Peripheral neuropathy,with clinical manifestations of pain,sensory,autonomic and even motor dysfunctions,is a ......
Neonatal maternal deprivation sensitizes voltage-gated sodium channel currents in colon specific dor
Background & Aims: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain ......
Objective Lysophosphatidic acid(LPA),a lipid metabolite released by injured tissues and tumor,is a key mediator in cance......
Evoked-bursting from injured dorsal root ganglion neurons might act as a tactile allodynia pain sign
Objective Tactile allodynia is one of the common features of peripheral neuropathy in which myelinated Aβ fibers were p......
Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassiu
Bis(7)-tacrine [bis(7)-tetrahydroaminacrine],a dimeric acetylcholinesterase (AChE) inhibitor,is composed of two tacrine ......
Epigenetic Mechanisms of Adrenergic Signaling via miR-31 Downregulation in Visceral Hypersensitivity
Objectives: The pathogenesis of irritable bowel syndrome(IBS)remains largely unknown and treatment options are very limi......
Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induc
Background: Cancer-induced pain(CIP)is one of the most severe types of chronic pain with which clinical treatment remain......
Downregulation of G protein coupled receptor kinase 6 mediates chronic visceral hypersensitivity thr
Objective The pathogenesis of irritable bowel syndrome(IBS)remains poorly understood and treatment options are very limi......
Different roles of Notch signaling in the development of dorsal root ganglion and trigeminal ganglio
Somatosensory ganglia including dorsal root ganglion (DRG) and trigeminal ganglion (TG) are derived from a common pool o......
The effect of dexmedetomidine on tetrodotoxin-resistant Nav1.8 current in rat dorsal root ganglion n
Aim of investigation: To study the effect of dexmedetomidine, a selective alpha 2 adrenergic receptor (α2-AR) agonist, ......
Objective: The mechanism of pain in chronic pancreatitis(CP)is poorly understood and its treatment remains difficult,in ......
Although mature CNS axons do not spontaneously regenerate,conditioning injury to the peripheral branches of sensory neur......
Ethnopharmacological relevance: Neuropathic pain was regarded as a main form of chronic pain condition that remains diff......
Increased autophagic activity in dorsal root ganglion attenuates neuropathic pain following peripher
Autophagy is a process of cellular self-cannibalization, and provides an adaptive mechanism to protect cells against div......
Enhanced Binding Capability of Nuclear Factor-κB with Demethylated P2X3 receptor Gene Contributes to
Objective: Nuclear factor-kappa B (NF-κB) signaling is implicated in both cancer development and inflammation processes......
Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induc
Background: Cancer-induced pain (CIP) is one of the most severe types of chronic pain with which clinical treatment rema......
The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood and treatment remains difficult.The pres......
Promoted interaction of nuclear factor-kappa B with demethylated purinergic P2X3 receptor gene contr
Painful diabetic neuropathy is a common complication of diabetes by mechanisms that as yet are incompletely defined.The ......
Inhibition of cystathionine β-synthetase desensitizes sodium channel activities of dorsal root gangl
Background: The pathogenesis of pain in lumber disc herniation (LDH) remains poorly understood.We have previously report......
FXYD2, a γ subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammati
Objective Na+,K+-ATPase (NKA) is required to generate the resting membrane potential in neurons.Our previous study showe......
Background and Aims: The mechanism of pain in chronic pancreatitis(CP)is poorly understood and its treatment remains dif......
Purinergic signaling contributes significantly to cutaneous, musculoskeletal and visceral nociception and on the roles p......
Retinoids are structurally related derivatives of vitamin A and are required for normal vision as well as cell prolifera......
TTX-sensitive (TTX-S) Navl.3 sodium channel is barely detectable in adult DRG or spinal cord.After nerve injury,however,......
Analgesic Efficacy and Mechanism of Pulsed Radiofrequency: A New Clinical Development from Knowledge
Application of pulsed radiofrequency (PRF) adjacent to dorsal root ganglion (DRG) and peripheral nerve has been widely u......
Epigenetic regulation of the endogenous hydrogen sulfide producing enzyme in irritable bowel syndrom
Irritable bowel syndrome (IBS) is characterized by persistent or recurrent abdominal pain with altered bowel movement in......
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目的探讨大鼠背根神经节(DRG)持续受压(CCD)后DRG中膜联蛋白A2(ANXA2)的表达及分布规律。方法成年雄性Wistar大鼠102只按随机数字......
Hydrogen sulfide (H2S) is a well-known toxic gas that has the smell of rotten eggs.This pungent gas is synthesized f......
Most current studies quantify axon regeneration by immunostaining regeneration-associated proteins, representing indirec......
Increased gene and protein expressions of the transient receptor potential vanilloid receptor 4 foll
Dorsal root ganglion (DRG) neurons from newb Wistar rats cultured in vitro were pressurized with 20, 40, 80 or 120 mm Hg......
Dorsal root ganglion progenitors differentiate to gamma-aminobutyric acid- and choline acetyltransfe
This study examined the isolation and differentiation of dorsal root ganglion progenitor cells for therapeutic use in ne......
